Healthy lifestyle benefits those with diabetes

January 28th, 2010 by admin

Research presented Tuesday at the 20th World Diabetes Congress in Montreal provides further evidence that healthy behaviors reduce mortality in people with and without diabetes.

“Few previous studies have measured the effectiveness of healthy behaviors in delaying mortality among adults with diagnosed diabetes,” lead researcher Dr. Sharon Saydah told Reuters Health. “We looked at the association of health behaviors with mortality in the general U.S. population among both adults with and without diabetes.”

The study included 1,177 people with diabetes and 15,217 without diabetes who took part in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and were followed through 2001.

A greater number of healthy behaviors was linked to a 15 percent reduced risk of dying from any cause in diabetics and a 17 percent reduced risk in non-diabetics, after adjusting for various factors that might influence the results.

Subjects in the top 20 percent of healthy behavior “summary scores” had a 58 percent lower death rate than those in the bottom 40 percent.

Five self-reported healthy behaviors were assessed at the start of the study: physical activity, not smoking, higher healthy eating index, moderate alcohol intake (1-2 drinks per week), and maintaining weight or trying to lose weight in the past 12 months.

“Among the healthy behaviors studied, regular, moderate to vigorous physical activity was most protective for those with diabetes,” said Saydah, a senior scientist with the Centers for Disease Control and Prevention, Atlanta.

Moderate to vigorous physical activity significantly reduced the risk of dying in both adults with and without diabetes, whereas moderate alcohol use, was only protective only in people with diabetes.

In diabetes-free adults, current smoking and fewer healthy eating habits were both linked to increased risk of death, whereas the impact of diet on death in people with diabetes was inconclusive.

“These results provide information to health care providers and the general public on stressing the importance of … lifestyle factors such as physical activity in delaying mortality,” Saydah said.

Heart Failure Treatment Underused

January 21st, 2010 by admin

A recommended treatment for heart failure is underused in U.S. hospitals, a new study finds.

The use of aldosterone antagonist therapy in patients with heart failure is designated as “useful and recommended” in chronic heart failure guidelines established by the American College of Cardiology/American Heart Association (ACC/AHA), but this study found that less than one-third of patients hospitalized for heart failure receive the treatment.

Researchers analyzed data on 43,625 patients admitted with heart failure and discharged home from 241 hospitals participating in a hospital recognition program called Get With The Guidelines — HF between 2005 and 2007.

The study found that 12,565 patients (28.8 percent) from 201 hospitals met ACC/AHA heart failure management guidelines criteria, and 4,087 eligible patients received an aldosterone antagonist when they were discharged from hospital. Overall, treatment increased from 28 percent to 34 percent during the study period, but there was wide variation in aldosterone antagonist use among hospitals — ranging from 0 percent to 90.6 percent.

“Aldosterone antagonist use in eligible patients was associated with younger age, African-American race/ethnicity, lower systolic blood pressure, history of implantable cardioverter-defibrillator use, depression, alcohol use and pacemaker implantation, and with having no history of renal insufficiency,” wrote Nancy M. Albert of the Cleveland Clinic and colleagues.

“These data confirm that in the context of a hospital-based performance improvement program, aldosterone antagonist therapy can be used according to guidelines with little inappropriate use. Given the substantial morbidity and mortality risk faced by patients hospitalized with HF and the established efficacy of aldosterone antagonist prescription in HF, a stronger uptake of aldosterone antagonist therapy indicated by evidence-based guidelines may be warranted,” the researchers concluded.

Leg Clots May Not Travel to Lungs

January 14th, 2010 by admin

New research raises doubts about the long-held medical dogma that dangerous blood clots in the lungs, known as pulmonary emboli, originate from clots in the deep veins of the legs or other parts of the lower body, which then break up and travel up through the body.

A study appearing in the October issue of the Archives of Surgery found that 85 percent of trauma patients with pulmonary emboli showed no sign of deep vein thrombosis, or blood clots in the lower extremities.

The lead author of the study, Dr. George Velmahos, chief of the division of trauma, emergency surgery and surgical critical care at Massachusetts General Hospital and professor of surgery at Harvard Medical School in Boston, said the findings also cast doubt on the use of filters to prevent the clots from traveling.

But an outside expert said the findings need to be received cautiously, at least for now.

“I think it’s an interesting report. I wouldn’t call it a bombshell”, said Dr. Jack Ansell, chairman of the department of medicine at Lenox Hill Hospital in New York City. “I think this study by no means answers this question or reverses the original concept that most pulmonary embolisms originate as venous thrombosis [blood clots] in the deep veins of leg or sometimes in pelvis or abdomen.”

According to Velmahos, the concept of clots in the lungs originating as clots in the legs has never been challenged, despite evidence in the literature that some patients suffering from pulmonary embolism did not show signs of having had a blood clot in the lower extremities.

For this study, Velmahos and co-authors looked back over medical records of 247 trauma patients who had undergone CT pulmonary angiography and CT venography.

Among 46 patients with PE, only 7 also had DVT, or 15 percent.

There are possible explanations, the team said. It’s possible that the entire original clot detached itself, leaving no traces. However, cadaver studies suggest that only a part of the leg clot breaks away, and a remnant is typically left behind. Or it could be that small clots exist and were not picked up by imaging techniques or even that the clots start in the upper extremities, which are not routinely examined.

Ansell also pointed to what he believes are several shortcomings in the study.

“There are still some issues that could account for why they didn’t see DVTs,” Ansell said. “The screening methods may not be ideal [and] small clots in calf veins are difficult to visualize by various techniques.”

“Having said that, there certainly is the possibility with certain types of injury that there could be clots formed just primarily in the lungs and not necessarily travel from other spots,” he added.

Velmahos felt that he had already excluded potential reasons for not seeing lower-extremity clots in pulmonary embolism patients, and said he is “very confident that a correlation cannot be established.” Yet he also acknowledged that “every retrospective study [which this is] should be viewed with a grain of salt.”

More studies need to be conducted, particularly to explore the hypothesis that pulmonary emboli actually form first in the lungs.

If it turns out that DVTs do not travel far from the legs, do tiny filters now used to trap them remain useful therapy? One expert said that issue may be a minor one.

“Pulmonary embolism and DVT are huge problems in trauma patients. The question is how to treat them,” said Dr. David Gillespie, a professor of surgery at the University of Rochester Medical Center. “Anticoagulants such as heparin have been the standard of care… The interpretation here should not be that all filters are bad [but] anticoagulants should be the main therapy.”

Finally, even if DVTs don’t detach and travel to the lungs, “this does not mean that DVT is unimportant,” Ansell said. “It is clearly established that most or many pulmonary emboli do originate in the legs in the lower extremities and one still needs to provide appropriate anticoagulant [blood-thinning] prophylaxis in patients who are at risk, whether they are trauma patients or just patients immobilized for other reasons in the hospital.”

New IVF Guidelines Aim to Reduce Multiple Births

January 7th, 2010 by admin

In an effort to reduce multiple births following fertility treatment, the American Society for Reproductive Medicine has revised its recommendations on the number of embryos that should be transferred during in vitro fertilization procedures.

The society reports that the guidelines are now different in two major ways.

For one, it says that doctors should only use one more embryo than called for in patients whose prognosis is less optimistic. Even in those with poor prognosis, no more than one extra embryo should be transferred.

The society also calls on doctors to advise patients about the risks of a pregnancy with several fetuses and to make notations about extra embryos and counseling in medical records.

The guidelines also make it clear that it doesn’t make any difference whether transferred embryos are fresh or frozen. The recommended number remains the same.

The society issued guidelines more than 10 years ago and says they have cut down on births with high numbers of babies by almost 60 percent.

“It is clear that these guidelines have a terrific impact on clinical practice. Over the years we have seen a reduction in the number of high order multiple births while maintaining strong success rates. This latest revision is our most recent effort to help our members provide their patients with the best, safest care possible,” said Dr. R. Dale McClure, president of the American Society for Reproductive Medicine, in a statement.

Sex With New Partners Raises Widowers’ Disease Risk

December 27th, 2009 by admin

Older widowers who recently lost their wives are more likely to have a sexually transmitted disease than their counterparts who are still married, a new study has found.

The researchers behind the study add that drugs like Viagra could boost the risk, noting the widowers might be seduced by advertisements for sexual enhancement.

The risk that seniors have a sexually transmitted disease remains extremely low, at less than 1 percent, study co-author and Harvard researcher Kirsten Smith explained in a news release about the study.

“Nonetheless,” Smith said, “older adults need to be aware that they are at risk of contracting a sexually transmitted infection if they take on a new sexual partner following a spouse’s death.”

The researchers examined data from more than 400,000 U.S. couples, who were aged 67 to 99 years in 1993.

Within six months to a year after their wives died, men were 16 percent more likely to be infected with a sexually transmitted disease. And for recently widowed men, the risk of having a sexually transmitted disease rose by 83 percent after 1998. That’s the year that Viagra went on the market as a treatment for erectile dysfunction.

“For men ages 67 and older, the age group that we studied, the use of medications for erectile dysfunction may contribute to that risk by making sex possible,” Smith said.

Gonorrhea was the most common STD in the men, the study authors noted.

Rising Heat, Humidity Raise Risk of Asthma Flares

December 18th, 2009 by admin

Although many parents already know that changes in the weather can cause their children’s asthma symptoms to flare up, a new study backs up their intuition.

If the humidity levels in the air rose by more than 10 percent or if the temperature increased by more than 10 degrees Fahrenheit in a single day, more children ended up in the emergency department of a Detroit hospital reporting asthma symptoms, the new research found.

“Parents need to be mindful of days when there are dramatic changes in temperature or humidity. A child’s asthma may flare more on those days,” said study senior author Dr. Alan Baptist, director of the University of Michigan asthma program, in Ann Arbor.

The findings were published in the September issue of the Annals of Allergy, Asthma & Immunology.

As many as 9 million children in the United States have asthma, according to the background information in the study. There are numerous known triggers that can exacerbate the inflammatory airway disease, including viral infections, air pollution, exposure to tobacco smoke and airborne allergens, such as pollen, the study authors noted.

Baptist said that another asthma trigger reported by many parents is weather changes. While some past studies have looked at this phenomenon, Baptist and his colleagues pointed out that none of the previous studies controlled for air pollution and airborne allergens.

For the current study, the researchers reviewed data from two years of emergency department admissions for asthma at Children’s Hospital of Michigan in Detroit. During the study time period — Jan. 1, 2004 through Dec. 31, 2005 — more than 25,000 youngsters between the ages of 1 and 18 were admitted for an asthma exacerbation, according to the study. That works out to about 35 children a day, according to Baptist.

The researchers then reviewed weather data for that time period, along with data on airborne allergens and air pollution. And, their statistical model was designed to control for these factors, Baptist added.

“A 10 percent increase in humidity two days before the admission day was associated with one additional visit to the emergency department,” said Baptist. “For temperature, an interday change of 10 degrees one day before the admission resulted in two additional visits.”

Although previous studies have found an association between barometric pressure and asthma symptoms, the current study found no link.

Asked why weather changes might affect asthma symptoms, Baptist said, “Asthma, at its core, is inflammation of the airways, and maybe these changes could be triggering more inflammation. But, it’s really unknown why temperature and humidity changes exacerbate asthma, and it should be looked at further.”

“This study brings up good discussion points, but I don’t think this is going to be strong enough evidence to change practice,” said Dr. Shean Aujla, a pediatric pulmonologist at Children’s Hospital of Pittsburgh.

Aujla said that cold air is a known trigger for asthma, and confirmed that many parents say a change in weather triggers their children’s asthma symptoms.

Until more research is done, she recommended focusing on each child’s individual symptoms. “If your child is going outside to play and having persistent symptoms, they should use their albuterol inhaler whether or not it’s humid,” said Aujla.

And, she added, very few children need to stay inside because of their asthma and weather changes. “Unless a child has very severe asthma, I wouldn’t say stay indoors,” she said.

FDA: Philips Lifeline Issues Safety Alert for Lifeline Pendant Personal Help Buttons

December 11th, 2009 by admin

The U.S. Food and Drug Administration today cautioned users of personal emergency response buttons worn around the neck of a potential choking hazard associated with this product.

The FDA is aware of at least six reports between 1998 and 2009 of serious injury or death, including three deaths in the United States and one in Canada, from choking after the cord on the Philips Lifeline Personal Help Button became entangled on other objects worn around the neck.

There are more than 750,000 users of these devices in the United States and Canada. By pushing the “help” button on the device when in distress, users can call for emergency assistance to their home. According to Philips Lifeline, the device is used primarily by seniors living independently, who feel they are at risk for falls or other medical emergencies.

The Lifeline pendant button is intentionally designed to not break away when tugged, which prevents the button from accidentally falling off. However, because it does not break away, there is a risk of choking, including the possibility of serious injury or death. Risks are greater for those with mobility limitations or for those who use wheelchairs, walkers, beds with guard rails, or other objects that could entangle with a neck cord.

Philips Lifeline is currently sending letters to its 750,000 customers and has changed the labeling of this product to include a warning against the potential choking hazard.

The FDA recommends that users consult their health care providers to determine which style of emergency button, including those that are worn on the wrist, is most beneficial for them.

These widely used devices provide critical and immediate access to emergency care for those at risk of falls or who may be more likely to need outside assistance. While the number of adverse events reported is small compared to the number of people who use this device, the severity of these events is of concern. It remains important that users, along with their health care providers, assess the options provided by each style of button, and choose the option that best fits their condition.

Health care professionals and users may report serious adverse events or product quality problems with the use of this product to the FDA’s MedWatch Adverse Event Reporting program either online, by regular mail, fax or phone.

Med Students Posting Unprofessional Messages: Survey

December 5th, 2009 by admin

Many U.S. medical schools have had cases of medical students posting unprofessional content online, including incidents where patient confidentiality was violated, according to a new study. It also found that few schools have policies to deal with such transgressions.

Researchers sent an anonymous survey to 130 medical schools in the Association of American Medical Colleges and received 78 responses. Of the schools that responded, 47 (60 percent) reported incidents involving students posting unprofessional content.

In the past year, six of those schools had no incidents, 36 had fewer than five incidents, three had five to 15 incidents, and one was aware of incidents but did not know how many, according to Dr. Katherine C. Chretien, of the Washington, D.C., VA Medical Center, and colleagues.

“Incidents involving violation of patient confidentiality in the past year were reported by 13 percent (6/46). Student use of profanity, frankly discriminatory language, depiction of intoxication, and sexually suggestive material were more commonly reported,” Chretien wrote in a news release.

“Of 45 schools that reported an incident and responded to the question about disciplinary actions, 30 gave informal warning (67 percent) and 3 reported student dismissal (7 percent). Policies that cover student-posted online content were reported by 38 percent (28/73) of deans. Of schools without such policies, 11 percent (5/46) were actively developing new policies to cover online content. Deans reporting incidents were significantly more likely to report having such a policy (51 percent vs. 18 percent), believing these issues could be effectively addressed (91 percent vs. 63 percent;), and having higher levels of concern,” she added.

The researchers recommended a number of ways to address the concerns identified in the study.

“The formal professional curriculum should include a digital media component, which could include instruction on managing the ‘digital footprint,’ such as electing privacy settings on social networking sites and performing periodic Web searches of oneself. This is important given that residency program directors, future employers, and patients may access this information,” they said.

Also, “discussions among students, residents, and faculty should occur to help define medical professionalism in the era of Web 2.0,” the researchers concluded.

The study appears in the Sept. 23-30 issue of the Journal of the American Medical Association, a theme issue on medical education.

Rich, Poor See Similar Declines in Old Age

November 25th, 2009 by admin

Socioeconomic status seems to make no difference in mental decline after the age of 70, according to new research.

The study, published in the Aug. 1 issue of the American Journal of Epidemiology, challenges claims that economic status and background have an impact on cognitive functioning among the elderly. Rather, the University of California, Los Angeles study found that rates of cognitive decline among people aged 70 and older depended on other factors and were similar across socioeconomic and racial/ethnic groups.

“It has been known that cognitive performance at any given age appears to depend on demographic characteristics; the more educated, for instance, perform better,” said lead investigator Dr. Arun Karlamangla, associate professor of medicine at UCLA’s David Geffen School of Medicine, in a university news release. “But though there are differences in the level of performance you start with in your late 60s, this study’s surprise is that the rate of decline in your 70s is the same for every group.”

The study authors looked at data collected from 6,476 people born before 1924 who took part in the study of Assets and Health Dynamics Among the Oldest Old. Participants were tested five times between 1993 and 2002 on various memory and cognition tasks, including word recall, subtraction, attention, language and knowledge of current affairs.

The researchers found that cognitive decline depended on how active people were earlier in life, whether or not they were widowed or ever married, and how old they were. Other social factors appeared to have little impact.

“The most consistent predictors of faster declines in cognitive functioning were being old and being single,” the study authors wrote.

Routine pre-exercise heart check often not needed

November 15th, 2009 by admin

Most generally healthy adults starting an exercise program do not need to see their doctor first, researchers say.

Routine medical screening before starting a regular exercise regimen with the goal of reducing the risk of sudden exercise-induced death is not recommended, the researchers wrote in a report published this month.

“Sudden death is a rare adverse effect of exercise,” Dr. Mayer Brezis, of Hadassah Hebrew University Medical Center, Jerusalem, Israel, told Reuters Health in an interview.

“Medical screening before initiating regular exercise is often advised but without scientific basis,” Brezis noted.

An exercise electrocardiogram — a test that detects and records the heart’s electrical activity — is thought to help identify people at risk but the test yields “many” falsely positive and falsely negative test results, the researcher warned.

In a “simulation study,” Brezis and colleagues found that routine screening decreases deaths in intermediate to high-risk people but not in those who are at low risk.

“Actually, medical screening may cause damage,” Brezis said, “for instance because of labeling healthy people as sick or because of the side effects” of tests to check for heart disease.

“Medical screening may actually prevent the known benefit from exercise by diverting attention from the main goal: i.e., to have people exercise,” Brezis said.

“Sedentary people should be encouraged to initiate exercise gradually and go to a physician if they feel chest discomfort or dizziness during exercise,” Brezis said.

“Gyms should post boards explaining these warning signs. Exercise coaches should understand and explain these warning signs to customers,” he added.

Still, Brezis emphasized that this advice does not apply to individuals with known heart disease. “These people should be referred to cardiac rehabilitation centers where they can resume physical activity under supervision.”